Profile Response Detail


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Molecular Profile CTNNB1 S33Y
Therapy Mps1-IN-1
Indication/Tumor Type colorectal adenocarcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive Mps1-IN-1 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y demonstrated increased sensitivity to Mps1-IN-1 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
PubMed Id Reference Title Details
(28751540) TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers. Full reference...