Profile Response Detail

Molecular Profile Unknown unknown
Therapy Gemcitabine + Milciclib
Indication/Tumor Type Advanced Solid Tumor
Response Type not applicable
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Gemcitabine + Milciclib Phase I Actionable In a Phase I trial, the combination therapy of Gemzar (gemcitabine) and Milciclib (PHA-848125AC) resulted in a clinical benefit in 36% (5/14) of patients with an advanced solid tumor, including long-term stable disease (6-14 months) in four patients and a partial response in a patient with non-small cell lung carcinoma (PMID: 28424962). 28424962
PubMed Id Reference Title Details
(28424962) Phase I dose-escalation study of milciclib in combination with gemcitabine in patients with refractory solid tumors. Full reference...