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Molecular Profile | Unknown unknown |
Therapy | Triptolide |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | triple-receptor negative breast cancer | not applicable | Triptolide | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with Triptolide (C1572) decreased Myc protein expression, decreased cancer stem-like cell (CSC) number, and induced senescence in a triple-negative breast cancer (TNBC) cell line in culture, and depleted CSCs and reduced tumor growth in TNBC cell line xenograft models (PMID: 28951456). | 28951456 |
PubMed Id | Reference Title | Details |
---|---|---|
(28951456) | MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer. | Full reference... |