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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ALK I1171N ALK L1198F ALK rearrange||lung non-small cell carcinoma||resistant||Lorlatinib||Case Reports/Case Series||Actionable||In a clinical study, a non-small cell lung cancer patient harboring ALK I1171N and L1198F in cis in the context of EML4-ALK demonstrated primary resistance to Lorlatinib (PF-06463922) (PMID: 29650534).||29650534|