Profile Response Detail

Molecular Profile KRAS G12S
Therapy Afatinib
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
Create By cstatz
Update By cstatz

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12S lung adenocarcinoma sensitive Afatinib Preclinical - Cell line xenograft Actionable In a preclinical study, lung adenocarcinoma cells harboring KRAS G12S were sensitive to treatment with Gilotrif (afatinib), demonstrating decreased cell proliferation and reduced Erk, Mek, and Akt activity in culture, and decreased tumor growth in cell-line xenograft models (PMID: 29925635). 29925635
PubMed Id Reference Title Details
(29925635) Afatinib restrains K-RAS-driven lung tumorigenesis. Full reference...