Profile Response Detail

Molecular Profile RET M918T RET V804M
Therapy Alectinib
Indication/Tumor Type lung adenocarcinoma
Response Type resistant
Create By cstatz
Update By rajadg

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET M918T RET V804M lung adenocarcinoma resistant Alectinib Case Reports/Case Series Actionable In a clinical case study, a patient with lung adenocarcinoma initially treated with chemotherapy and immunotherapy was found to harbor KIF5B-RET, and was then treated with Alecensa (alectinib), which resulted in an intracranial response, but eventually led to further progression (PMID: 29912274; NCT03157128). 29912274
PubMed Id Reference Title Details
(29912274) Selective RET Kinase Inhibition for Patients with RET-Altered Cancers. Full reference...