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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF V600E||melanoma||sensitive||Encorafenib||Preclinical - Cell line xenograft||Actionable||In preclinical studies, Encorafenib (LGX818) treatment of human melanoma xenograft models with BRAF V600E significantly decreased Mek activation and resulted in tumor regression (Cancer Res: 72(8) Suppl 1, Abstract #3790).||detail...|
|PubMed Id||Reference Title||Details|
|Abstract 3790: Preclinical profile of LGX818: A potent and selective RAF kinase inhibitor||Full reference...|