Profile Response Detail


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Molecular Profile BRAF L597S
Therapy Vemurafenib
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF L597S Advanced Solid Tumor sensitive Vemurafenib Preclinical Actionable In a preclinical study, treatment of cells expressing BRAF L597S with the BRAF inhibitor, Zelboraf (vemurafenib), decreased activation of MEK and ERK (PMID: 22798288). 22798288
PubMed Id Reference Title Details
(22798288) BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors. Full reference...