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Molecular Profile Unknown unknown
Therapy MK-1248 + Pembrolizumab
Indication/Tumor Type Advanced Solid Tumor
Response Type not applicable


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable MK-1248 + Pembrolizumab Phase I Actionable In a Phase I trial, MK-1248 in combination with Keytruda (pembrolizumab) demonstrated safety and resulted in an objective response response rate of 18% (3/17, one complete and two partial responses) and a disease control rate of 47% (8/17) in patients with advanced solid tumors (PMID: 32809217; NCT02553499). 32809217
PubMed Id Reference Title Details
(32809217) First-in-human phase 1 study of MK-1248, an anti-glucocorticoid-induced tumor necrosis factor receptor agonist monoclonal antibody, as monotherapy or with pembrolizumab in patients with advanced solid tumors. Full reference...