Profile Response Detail


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Molecular Profile KIT positive
Therapy Imatinib + Letrozole
Indication/Tumor Type breast cancer
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT positive breast cancer predicted - sensitive Imatinib + Letrozole Phase 0 Actionable In a pilot trial, Gleevec (imatinib mesylate) and Femara (letrozole) combination treatment resulted in clinical partial response in 90% (9/10) and stable disease in 10% (1/10) of the evaluable patients with invasive hormone-sensitive breast cancer, 8 of the 13 enrolled patients had KIT-positive tumors (PMID: 18248884). 18248884
PubMed Id Reference Title Details
(18248884) Evaluation of neoadjuvant inhibition of aromatase activity and signal transduction in breast cancer. Full reference...