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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PTPN11 T253M PTPN11 Q257L||lung non-small cell carcinoma||resistant||Selumetinib + SHP099||Preclinical - Cell culture||Actionable||In a preclinical study, pancreatic ductal adenocarcinoma cells co-expressing PTPN11 T253M and PTPN11 Q257L were resistant to the combination therapy, Selumetinib (AZD6244) and SHP099, in culture (PMID: 30045908).||30045908|