Profile Response Detail

Molecular Profile BRCA2 inact mut
Therapy Talazoparib
Indication/Tumor Type Her2-receptor negative breast cancer
Response Type sensitive
Create By tyin
Update By tyin

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRCA2 inact mut Her2-receptor negative breast cancer sensitive Talazoparib FDA approved Actionable In a Phase III trial (EMBRACA) that supported FDA approval, Talzenna (talazoparib) treatment resulted in significantly longer median progression-free survival (8.6 vs 5.6 months, HR=0.54, p<0.001), and higher objective response rate (62.6% vs 27.2%, OR=5.0, p<0.001) compared to standard chemotherapy in patients with advanced ERBB2 (HER2)-negative breast cancer harboring known deleterious or suspected deleterious germline mutations in BRCA1 or BRCA2 (PMID: 30110579; NCT01945775). 30110579
PubMed Id Reference Title Details
(30110579) Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation. Full reference...