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Molecular Profile ETV6 - NTRK2
Therapy Larotrectinib
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ETV6 - NTRK2 acute myeloid leukemia sensitive Larotrectinib Case Reports/Case Series Actionable In a clinical study, a patient with secondary AML achieved a partial remission when treated with Vitrakvi (larotrectinib), showing complete elimination of the cell population harboring ETV6-NTRK2, and the patient-derived xenograft (PDX) model harboring ETV6-NTRK2 showed sensitivity to treatment with Vitrakvi (larotrectinib), demonstrating a decrease in ETV6-NTRK2-expressing cells (PMID: 29920189). 29920189
PubMed Id Reference Title Details
(29920189) Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies. Full reference...