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Molecular Profile AKT1 E17K
Therapy Capivasertib
Indication/Tumor Type uterus leiomyosarcoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 E17K uterus leiomyosarcoma predicted - sensitive Capivasertib Case Reports/Case Series Actionable In a Phase II (MATCH) trial, Capivasertib (AZD5363) treatment resulted in partial response in a patient with uterus leiomyosarcoma harboring AKT1 E17K mutation (PMID: 30429128; NCT02465060). 30429128
PubMed Id Reference Title Details
(30429128) Capivasertib Active against AKT1-Mutated Cancers. Full reference...