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Molecular Profile ARID1A dec exp
Therapy Molibresib
Indication/Tumor Type ovarian clear cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A dec exp ovarian clear cell carcinoma predicted - sensitive Molibresib Preclinical - Cell culture Actionable In a preclinical study, knockdown of ARID1A resulted in increased sensitivity to Molibresib (GSK525762) in ovarian clear cell carcinoma cell lines in culture (PMID: 29760405). 29760405
PubMed Id Reference Title Details
(29760405) ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors. Full reference...