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Molecular Profile | ERBB2 Y772_A775dup ERBB2 C805S |
Therapy | Pyrotinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB2 Y772_A775dup ERBB2 C805S | Advanced Solid Tumor | resistant | Pyrotinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing ERBB2 (HER2) Y772_A775dup (reported as A775_G776insYVMA) and an acquired ERBB2 (HER2) C805S were resistant to Pyrotinib in culture (PMID: 30527195). | 30527195 |
PubMed Id | Reference Title | Details |
---|---|---|
(30527195) | Activity of a novel HER2 inhibitor, poziotinib, for HER2 exon 20 mutations in lung cancer and mechanism of acquired resistance: An in vitro study. | Full reference... |