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Molecular Profile | ERBB2 Y772_A775dup |
Therapy | Luminespib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB2 Y772_A775dup | Advanced Solid Tumor | predicted - sensitive | Luminespib | Preclinical - Cell culture | Actionable | In a preclinical study, Luminespib (AUY922) inhibited growth of transformed cells expressing ERBB2 (HER2) Y772_A775dup (reported as reported as A775_G776insYVMA) in culture (PMID: 30527195). | 30527195 |
PubMed Id | Reference Title | Details |
---|---|---|
(30527195) | Activity of a novel HER2 inhibitor, poziotinib, for HER2 exon 20 mutations in lung cancer and mechanism of acquired resistance: An in vitro study. | Full reference... |