Profile Response Detail


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Molecular Profile BRAF N486_P490del
Therapy Trametinib
Indication/Tumor Type pancreatic ductal adenocarcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF N486_P490del pancreatic ductal adenocarcinoma predicted - sensitive Trametinib Case Reports/Case Series Actionable In a clinical case study, Mekinist (trametinib) treatment resulted in partial response in a patient with pancreatic ductal adenocarcinoma harboring BRAF N486_P490del 8 weeks after initiation of treatment and lasted for 6 months (PMID: 29903880). 29903880
PubMed Id Reference Title Details
(29903880) Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine. Full reference...