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Molecular Profile BRAF V600E MAP2K1 K57T
Therapy Vemurafenib
Indication/Tumor Type hairy cell leukemia
Response Type predicted - resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E MAP2K1 K57T hairy cell leukemia predicted - resistant Vemurafenib Case Reports/Case Series Actionable In a clinical case study, a single patient with hairy cell leukemia harboring BRAF V600E, who relapsed after a 38 week remission in response to Zelboraf (vemurafenib) treatment, was found to have acquired multiple clones with Mek/Erk activating mutations, of which the MAP2K1 K57T clone became dominant (PMID: 30341394). 30341394
PubMed Id Reference Title Details
(30341394) Targeting MEK in vemurafenib-resistant hairy cell leukemia. Full reference...