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Molecular Profile ERBB2 R784G
Therapy Cetuximab
Indication/Tumor Type colorectal cancer
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 R784G colorectal cancer predicted - resistant Cetuximab Case Reports/Case Series Actionable In a clinical study, ERBB2 R784G was identified in all 11 colorectal cancer patients who were resistant to Erbitux (cetuximab) treatment, and was associated with decreased survival rate (PMID: 30549033). 30549033
PubMed Id Reference Title Details
(30549033) HER2+ mCRC patients with exon 20 R784G substitution mutation do not respond to the cetuximab therapy. Full reference...