Profile Response Detail


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Molecular Profile PDGFRA D842V
Therapy Imatinib
Indication/Tumor Type Advanced Solid Tumor
Response Type resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRA D842V Advanced Solid Tumor resistant Imatinib Preclinical Actionable In a preclinical study, expression of PDGFRA D842V conferred resistance to Gleevec (imatinib) in cell culture (PMID: 15928335). 15928335
PDGFRA D842V Advanced Solid Tumor resistant Imatinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing PDGFRA D842V demonstrated resistance to Gleevec (imatinib) in culture (PMID: 30389923). 30389923
PubMed Id Reference Title Details
(15928335) PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. Full reference...
(30389923) Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies. Full reference...