Profile Response Detail

Molecular Profile TP53 wild-type
Therapy Pazopanib + Vorinostat
Indication/Tumor Type Advanced Solid Tumor
Response Type decreased response
Create By smockus
Update By spatt


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type Advanced Solid Tumor decreased response Pazopanib + Vorinostat Phase I Actionable In a Phase I study, patients with advanced solid tumor harboring TP53 mutations had increased progression-free survival and overall survival than TP53 wild-type patients after treatment with Votrient (pazopanib) in combination with Zolinza (vorinostat) (J Clin Oncol 32:5s, 2014 (suppl; abstr 2576)). detail...
PubMed Id Reference Title Details
A phase I trial of pazopanib and vorinostat: The role of TP53 mutations. Full reference...