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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||lung non-small cell carcinoma||not applicable||Abemaciclib + Ramucirumab||Phase Ib/II||Actionable||In a Phase Ib trial, the combination of Verzenio (abemaciclib) and Cyramza (ramucirumab) was well-tolerated and demonstrated preliminary activity in patients with previously treated metastatic non-small cell lung cancer, resulting in a response rate of 5% (2/39; all partial responses (PR)), a disease control rate of 54% (21/39; 2 PR and 19 stable disease), and a median progression-free survival of 4.83 months (95% CI, 2.60, 6.93) (PMID: 30082474; NCT02079636).||30082474|