Profile Response Detail


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Molecular Profile EML4 - NTRK3
Therapy Entrectinib
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - NTRK3 Advanced Solid Tumor predicted - sensitive Entrectinib Preclinical - Cell culture Actionable In a preclinical study, Rozlytrek (entrectinib) inhibited growth of transformed cells expressing EML4-NTRK3 in culture (PMID: 30279230). 30279230
EML4 - NTRK3 Advanced Solid Tumor predicted - sensitive Entrectinib Case Reports/Case Series Actionable In a Phase Ib/II trial (STARTRK-NG), a patient with an advanced solid tumor harboring EML4-NTRK3 demonstrated a partial response when treated with Rozlytrek (entrectinib) (Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 107-107; NCT02650401). detail...
PubMed Id Reference Title Details
(30279230) Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability-High Colorectal Cancers. Full reference...
Updated entrectinib data in children and adolescents with recurrent or refractory solid tumors, including primary CNS tumors. Full reference...