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Molecular Profile PTEN wild-type
Therapy 2-Methoxyestradiol
Indication/Tumor Type glioblastoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN wild-type glioblastoma sensitive 2-Methoxyestradiol Preclinical Actionable In a preclinical study, 2-Methoxyestradiol (2ME2) inhibited tumor-induced angiogenesis and reduced tumor growth in PTEN reconstituted GBM cell lines and mouse models (PMID: 24162827). 24162827
PubMed Id Reference Title Details
(24162827) PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. Full reference...