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Molecular Profile | ETV6 - NTRK3 |
Therapy | CH7057288 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ETV6 - NTRK3 | acute myeloid leukemia | sensitive | CH7057288 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, CH7057288 inhibited NTRK phosphorylation and downstream signaling and reduced growth of acute myeloid leukemia cells harboring ETV6-NTRK3 in culture, and induced tumor regression in xenograft models (PMID: 30242093). | 30242093 |
PubMed Id | Reference Title | Details |
---|---|---|
(30242093) | Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer. | Full reference... |