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Molecular Profile ETV6 - NTRK3
Therapy CH7057288
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ETV6 - NTRK3 acute myeloid leukemia sensitive CH7057288 Preclinical - Cell line xenograft Actionable In a preclinical study, CH7057288 inhibited NTRK phosphorylation and downstream signaling and reduced growth of acute myeloid leukemia cells harboring ETV6-NTRK3 in culture, and induced tumor regression in xenograft models (PMID: 30242093). 30242093
PubMed Id Reference Title Details
(30242093) Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer. Full reference...