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Molecular Profile ATM T1200Lfs*7 NRAS Q61K TP53 R213*
Therapy Olaparib
Indication/Tumor Type sarcoma
Response Type predicted - resistant


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM T1200Lfs*7 NRAS Q61K TP53 R213* sarcoma predicted - resistant Olaparib Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) treatment resulted in rapid disease progression in a patient with high-grade sarcoma harboring ATM T1200Lfs*7, NRAS Q61K, and TP53 R213* (PMID: 29304353). 29304353
PubMed Id Reference Title Details
(29304353) Yale Cancer Center Precision Medicine Tumor Board: two patients, one targeted therapy, different outcomes. Full reference...