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Molecular Profile TP53 R280M
Therapy Nutlin-3a
Indication/Tumor Type osteosarcoma
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 R280M osteosarcoma resistant Nutlin-3a Preclinical Actionable In a preclinical study, TP53 R280M resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018). 21643018
PubMed Id Reference Title Details
(21643018) Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3. Full reference...