Profile Response Detail

Molecular Profile TP53 P177T
Therapy Nutlin-3a
Indication/Tumor Type osteosarcoma
Response Type resistant
Create By c-xyi
Update By c-xyi

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 P177T osteosarcoma resistant Nutlin-3a Preclinical Actionable In a preclinical study, TP53 P177T resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018). 21643018
PubMed Id Reference Title Details
(21643018) Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3. Full reference...