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Molecular Profile | BARD1 V767fs |
Therapy | Cisplatin |
Indication/Tumor Type | cervical cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BARD1 V767fs | cervical cancer | sensitive | Cisplatin | Preclinical - Cell culture | Actionable | In a preclinical study, cisplatin treatment of HeLa cells expressing Bard1 P707S were more sensitive than wild-type Bard1 expressing cells, as demonstrated by decreased colony formation (PMID: 30925164). | 30925164 |
PubMed Id | Reference Title | Details |
---|---|---|
(30925164) | Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity. | Full reference... |