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Molecular Profile FGFR2 - DDX21
Therapy Debio 1347
Indication/Tumor Type cholangiocarcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - DDX21 cholangiocarcinoma sensitive Debio 1347 Case Reports/Case Series Actionable In a Phase I trial, Debio 1347 treatment resulted in stable disease in a patient with cholangiocarcinoma harboring FGFR2-DDX21 (PMID: 30745300; NCT01948297). 30745300
FGFR2 - DDX21 cholangiocarcinoma sensitive Debio 1347 Case Reports/Case Series Actionable In a clinical case study, treatment with Debio 1347 resulted in stable disease for 5.5 months in a patient with cholangiocarcinoma harboring an FGFR2-DDX21 fusion (PMID: 34250419). 34250419
PubMed Id Reference Title Details
(30745300) A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations. Full reference...
(34250419) Noninvasive Detection of Polyclonal Acquired Resistance to FGFR Inhibition in Patients With Cholangiocarcinoma Harboring FGFR2 Alterations. Full reference...