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Molecular Profile FLT3 D835Y IDH1 R132H
Therapy AGI-5198 + Crenolanib
Indication/Tumor Type hematologic cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 D835Y IDH1 R132H hematologic cancer sensitive AGI-5198 + Crenolanib Preclinical - Cell culture Actionable In a preclinical study, Crenolanib, in combination with AGI-5198, synergistically decreased cell proliferation of transformed mouse cells expressing Flt3 D835Y and Idh1 R132H (PMID: 30651561). 30651561
PubMed Id Reference Title Details
(30651561) Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Full reference...