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Molecular Profile BRAF K601E MAP2K1 V211D
Therapy Binimetinib
Indication/Tumor Type colon cancer
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF K601E MAP2K1 V211D colon cancer resistant Binimetinib Preclinical - Pdx Actionable In a preclinical study, Mektovi (binimetinib) did not inhibit Rsk and Erk phosphorylation, and had no effect on tumor growth in patient-derived xenograft (PDX) models of metastatic colon cancer harboring BRAF K601E and MAP2K1 V211D (PMID: 31227518). 31227518
PubMed Id Reference Title Details
(31227518) V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. Full reference...