Profile Response Detail

Molecular Profile KRAS G12D
Therapy Selumetinib
Indication/Tumor Type lung adenocarcinoma
Response Type decreased response
Create By c-xyi
Update By c-xyi


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12D lung adenocarcinoma decreased response Selumetinib Preclinical Actionable In a preclinical study, the treatment of a mouse model lung adenocarcinoma harboring the KRAS G12D mutant with selumetinib, a MEK inhibitor, resulted in modest tumor regression (PMID: 19029981). 19029981
PubMed Id Reference Title Details
(19029981) Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Full reference...