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Molecular Profile ALK rearrange ALK L1152R
Therapy Ceritinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK rearrange ALK L1152R lung adenocarcinoma predicted - resistant Ceritinib Case Reports/Case Series Actionable In a clinical case study, a patient with ALK-rearranged lung adenocarcinoma, which also harbored RB1 deletion and TP53 G154V and R158C mutations, demonstrated a partial response following treatment with Zykadia (ceritinib), however, progressed after 4 months and was found to have an acquired ALK L1152R mutation in a biopsy of a pleural nodule (PMID: 27091190). 27091190
PubMed Id Reference Title Details
(27091190) Acquired ALK L1152R Mutation Confers Resistance to Ceritinib and Predicts Response to Alectinib. Full reference...