Profile Response Detail


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Molecular Profile KIT exon 11 del KIT T670I
Therapy Ripretinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type decreased response


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT exon 11 del KIT T670I gastrointestinal stromal tumor decreased response Ripretinib Preclinical - Cell culture Actionable In a preclinical study, gastrointestinal stromal tumor cells harboring both KIT exon 11 deletion and KIT T670I demonstrated reduced response to growth inhibition by Qinlock (ripretinib) compared to cells harboring KIT exon 11 deletion alone in culture (PMID: 31085175). 31085175
PubMed Id Reference Title Details
(31085175) Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. Full reference...