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Molecular Profile DDR2 L239R DDR2 T654I
Therapy Dasatinib
Indication/Tumor Type lung squamous cell carcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DDR2 L239R DDR2 T654I lung squamous cell carcinoma predicted - resistant Dasatinib Preclinical - Cell culture Actionable In a preclinical study, DDR2 T654I was identified as an acquired mutation in lung squamous cell carcinoma cells harboring DDR2 L239R that became resistant to Sprycel (dasatinib) in culture (PMID: 24296828). 24296828
PubMed Id Reference Title Details
(24296828) Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss. Full reference...