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Molecular Profile | ATRX fusion |
Therapy | UNC1999 |
Indication/Tumor Type | neuroblastoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATRX fusion | neuroblastoma | predicted - sensitive | UNC1999 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with UNC1999 resulted in reduced proliferation and increased apoptosis of neuroblastoma cell lines harboring in-frame ATRX fusions in culture, and decreased tumor growth in a neuroblastoma cell line xenograft model harboring an ATRX fusion (PMID: 31631027). | 31631027 |
PubMed Id | Reference Title | Details |
---|---|---|
(31631027) | ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. | Full reference... |