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Molecular Profile TP53 wild-type
Therapy JQ1
Indication/Tumor Type medulloblastoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type medulloblastoma sensitive JQ1 Preclinical Actionable In a preclinical study, medulloblastoma cell lines with TP53 mutations had significantly less sensitivity to the BET inhibitor, JQ1, than cell lines carrying wild-type TP53 (PMID: 24231268). 24231268
PubMed Id Reference Title Details
(24231268) BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Full reference...