Profile Response Detail

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Molecular Profile BRAF T310I
Therapy Dabrafenib
Indication/Tumor Type breast cancer
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF T310I breast cancer predicted - resistant Dabrafenib Preclinical Actionable In a preclinical study, Tafinlar (dabrafenib) treatment resulted in increased Erk phosphorylation in breast cancer cells expressing BRAF T310I in culture (PMID: 31158244). 31158244
PubMed Id Reference Title Details
(31158244) Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition. Full reference...