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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 amp||colorectal cancer||sensitive||eFT226||Preclinical - Cell line xenograft||Actionable||In a preclinical study, eFT226 inhibited cell growth, and induced apoptosis in a FGFR2-amplified colorectal cancer cell line in culture, and inhibited tumor growth, and induced regression in a cell line xenograft model (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B133).||detail...|
|PubMed Id||Reference Title||Details|
|eFT226, a first in class inhibitor of eIF4A1, targets FGFR1/2 and HER2 driven cancers||Full reference...|