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Molecular Profile FGFR2 amp
Therapy eFT226
Indication/Tumor Type colorectal cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 amp colorectal cancer sensitive eFT226 Preclinical - Cell line xenograft Actionable In a preclinical study, eFT226 inhibited cell growth, and induced apoptosis in a FGFR2-amplified colorectal cancer cell line in culture, and inhibited tumor growth, and induced regression in a cell line xenograft model (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B133). detail...
PubMed Id Reference Title Details
eFT226, a first in class inhibitor of eIF4A1, targets FGFR1/2 and HER2 driven cancers Full reference...