Profile Response Detail

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Molecular Profile TP53 mutant
Therapy Osimertinib
Indication/Tumor Type lung non-small cell carcinoma
Response Type not predictive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant lung non-small cell carcinoma not predictive Osimertinib Clinical Study - Cohort Actionable In a retrospective analysis, patients with non-small cell lung cancer harboring TP53 mutations at treatment discontinuation of Tagrisso (osimertinib) had shorter time to treatment discontinuation (6.5 vs 11.5 months, p=0.0029) compared to patients with wild-type TP53 (PMID: 31839416). 31839416
PubMed Id Reference Title Details
(31839416) Next-generation sequencing based mutation profiling reveals heterogeneity of clinical response and resistance to osimertinib. Full reference...