Profile Response Detail

Molecular Profile FBXW7 loss
Therapy Sirolimus
Indication/Tumor Type colon cancer
Response Type sensitive
Create By c-spatt
Update By c-spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FBXW7 loss colon cancer sensitive Sirolimus Preclinical Actionable In a preclinical study, Rapamune (sirolimus) inhibited epithelial-mesenchymal transition, motility, and invasiveness in colon cancer cells lacking FBXW7 in culture (PMID: 23558291) 23558291
PubMed Id Reference Title Details
(23558291) Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. Full reference...