Profile Response Detail


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Molecular Profile NRAS G12D
Therapy Anti-CD19 CAR T cells
Indication/Tumor Type B-lymphoblastic leukemia/lymphoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G12D B-lymphoblastic leukemia/lymphoma predicted - sensitive Anti-CD19 CAR T cells Case Reports/Case Series Actionable In a clinical case study, an investigational CD19-directed CAR T cells therapy resulted in rapid elimination of leukemic cells, including a subclone harboring NRAS G12D, in a patient with relapsed Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia, the NRAS G12D subclone remained undetectable at disease progression 6 weeks after treatment (PMID: 31905241). 31905241
PubMed Id Reference Title Details
(31905241) Clinical response to larotrectinib in adult Philadelphia chromosome-like ALL with cryptic ETV6-NTRK3 rearrangement. Full reference...