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Molecular Profile Unknown unknown
Therapy Ibrutinib + Rituximab
Indication/Tumor Type CLL/SLL
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown CLL/SLL not applicable Ibrutinib + Rituximab FDA approved Actionable In a Phase III trial that supported FDA approval, combination of Imbruvica (ibrutinib) and Rituxan (rituximab) resulted in superior progression-free survival at 3 years (89.4% vs 72.9%, HR=0.35, p<0.001) and overall survival at 3 years (98.8% vs 91.5%, HR=0.17, p<0.001) compared to chemoimmunotherapy in patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (PMID: 31365801; NCT02048813). detail... 31365801
PubMed Id Reference Title Details
Imbruvica (ibrutinib) FDA Drug Label Full reference...
(31365801) Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia. Full reference...