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Molecular Profile PIK3CA E542K
Therapy Capivasertib
Indication/Tumor Type gastrointestinal system cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E542K gastrointestinal system cancer sensitive Capivasertib Preclinical - Cell culture Actionable In a preclinical study, gastric cancer cells harboring PIK3CA E542K demonstrated sensitivity to the AKT inhibitor AZD5363, resulting in decreased proliferation in culture (PMID: 24088382). 24088382
PubMed Id Reference Title Details
(24088382) The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere. Full reference...