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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||colorectal cancer||not applicable||TP-1454 + unspecified PD-1 antibody||Preclinical||Actionable||In a preclinical study, TP-1454 combined with an anti-PD1 antibody reduced tumor growth in a syngeneic mouse model of colorectal cancer, and synergistically inhibited tumor growth in another syngeneic mouse model (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B080).||detail...|
|PubMed Id||Reference Title||Details|
|Abstract B080: PKM2 activation modulates metabolism and enhances immune response in solid tumor models||Full reference...|