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|Molecular Profile||Unknown unknown|
|Therapy||TP-1454 + unspecified CTLA4 antibody + unspecified PD-1 antibody|
|Indication/Tumor Type||colorectal cancer|
|Response Type||not applicable|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||colorectal cancer||not applicable||TP-1454 + unspecified CTLA4 antibody + unspecified PD-1 antibody||Preclinical||Actionable||In a preclinical study, TP-1454 combined with an anti-CTLA4 and an anti-PD1 antibody inhibited tumor growth and increased survival in a syngeneic mouse model of colorectal cancer (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B080).||detail...|
|PubMed Id||Reference Title||Details|
|Abstract B080: PKM2 activation modulates metabolism and enhances immune response in solid tumor models||Full reference...|