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|Molecular Profile||PIK3CA E542K|
|Therapy||Alpelisib + Cetuximab + Radiotherapy|
|Indication/Tumor Type||head and neck squamous cell carcinoma|
|Response Type||predicted - sensitive|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA E542K||head and neck squamous cell carcinoma||predicted - sensitive||Alpelisib + Cetuximab + Radiotherapy||Case Reports/Case Series||Actionable||In a Phase Ib trial, 11 of 11 patients with metastatic head and neck squamous cell carcinoma demonstrated no evidence of disease at 3 to 4 months following treatment with Piqray (alpelisb) in combination with Erbitux (cetuximab) and intensity modulated radiation therapy (IMRT), and PIK3CA E545K was identified in one patient with oropharyngeal squamous cell carcinoma who had a near complete radiologic response within 8 days of starting IMRT (PMID: 31678634).||31678634|
|PubMed Id||Reference Title||Details|
|(31678634)||A Phase 1b Study of Cetuximab and BYL719 (Alpelisib) Concurrent with Intensity Modulated Radiation Therapy in Stage III-IVB Head and Neck Squamous Cell Carcinoma.||Full reference...|