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|Molecular Profile||PIK3CA E542K PIK3CA F744L|
|Indication/Tumor Type||head and neck squamous cell carcinoma|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA E542K PIK3CA F744L||head and neck squamous cell carcinoma||sensitive||Sulindac||Preclinical - Pdx||Actionable||In a preclinical study, Clinoril (sulindac) treatment reduced tumor growth rate in patient-derived xenograft (PDX) models of head and neck squamous cell carcinoma harboring PIK3CA mutations, including a model harboring PIK3CA E542K and PIK3CA F744L (PMID: 30683736).||30683736|
|PubMed Id||Reference Title||Details|
|(30683736)||Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer.||Full reference...|